The duo are headlining the latest horror epic from Justin Benson and Aaron Moorhead, the filmmaking duo who carved out a unique niche with The Endless, Spring and Resolution.
In Synchronic, a pair of New Orleans paramedics (Mackie and Dornan) stumble on malevolent forces when they are called to a crime scene to tend to the victims.
Mackie's Dennis Dannelly already has a life-changing medical diagnosis and a missing daughter, so the Lovecraftian entities he starts to encounter make him question the bounds of reality.
Although there's no UK release for the film announced yet, the US will be getting Synchronic in traditional cinemas and drive-in theatres across the country on October 23.
Another intriguing aspect of Synchronic is whether it follows The Endless in connecting with the universe of Benson and Moorhead's Resolution.
In a chat with Digital Spy, the filmmakers confirmed the interconnectedness of their films, while resisting calling them a "cinematic universe".
"We still haven't completely found anything that accurately describes it," Benson explained. "We like to say that they fit each other like puzzle pieces, or they complete each other's mysteries in some ways. But no, when we started making this, the idea of people thinking we were making a cinematic universe was a very scary arrogance to us. Like, 'Who watched Resolution? Nobody watched Resolution, but we're going to make another one'.
"We now realise that nobody seems to care, but it definitely offended our humility, but we wanted to tell the story, and we were just trying to find the right words for it."
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