Danielle Collins of the United States became the WTA's 14th first time champion of 2021 when she clinched the Palermo title on Sunday.
The 27-year-old top seed eased past Romanian qualifier Elena-Gabriela Ruse, 6-4, 6-2 in the final.
The American did not drop a set all week at the tournament.
Victory came after a tough year for Collins who was off tour between March and the French Open in May.
She had needed surgery to remove "a cyst the size of a tennis ball from my ovary", she told Britain's Daily Telegraph.