The 146th Open Championship - Royal Birkdale
Stenson and Spieth are scheduled to tee off with South Korean Kim Si-woo, who became the youngest winner at the Players Championship earlier this year, at 0947 local time (0847 GMT) on Thursday.
Stenson, who edged Phil Mickelson to win the title at Royal Troon last year, is bidding to become the first man since Padraig Harrington in 2008 to defend his title.
The first tee shot will be hit at 0635 local time by American Mark O'Meara, who was the winner in 1998 at Royal Birkdale.
(Reporting by Hardik Vyas in Bengaluru; Editing by Christian Radnedge)