But Willoughby made a special appearance on Thursday to welcome nine-year-old Sophie Fairall, who is battling a rare form of cancer and has just months to live.
Visiting This Morning was on Sophie's bucket list and she had revealed that Willoughby was her favourite on the show.
Langsford told Sophie that although the TV star wasn't there she had left her a gift.
Opening a box in front of her, Sophie took out the tiara that Willoughby wore when she dressed up as a princess for the This Morning Christmas panto.
“She was very sorry she couldn’t be here,” said Langsford, before adding: “But I think it won’t stop her talking to you!”
Sophie looked stunned as Willoughby then appeared on screen and said: “Hello Sophie!
"It’s so so lovely to meet you and I’m so sorry I can’t be there but when I heard you were coming on the show, I was like, ‘Right, I want to be there, I want to see her’ and I wish I could be there, but I’m sending you a big virtual cuddle through the screen.”
Willoughby said she’d been pondering what to give Sophie and decided on the sparkly tiara.
“And you’re a lucky girl because I asked if I could take that home for my daughter and they were like, ‘No, it has to remain here, it’s way too special for you to take home’ so you can have that with our love because I know you like that,” she said.
Willoughby also presented Sophie with the flask she used when she was Down Under on I’m A Celebrity… Get Me Out Of Here!
“Don’t worry, I’ve cleaned it out and shook out any spiders and bugs,” she said. “But that is a real bit of memorabilia. "I had that on set with me every day, so that’s my little piece of the jungle to give to you.”
Viewers posted messages on social media saying how touched they were by the moving segment.
“Such an inspirational young girl. My heart melted for her,” one person tweeted.
“I'm in tears watching Sophie. What an amazing young girl,” said another.
One viewer said the interview was “so special”.
This Morning airs weekdays from 10am on ITV and ITV Hub.